Ipamorelin – Mechanism of Action
There are numerous studies which indicated that ipamorelin has an effect on bone growth, weight and the production of growth hormone. It is one of the most efficient peptides in the release of growth hormone from the anterior lobe of the pituitary gland. It is a biosynthetic hormone that can be used to accentuate the release of growth hormone from pituitary cells on the anterior lobe. The mode of action is through biomimicry as the peptide is an endogenous hormone which acts like Ghrelin. However, unlike growth hormone releasing hexapeptide, it is more stable in suppressing the effects of somatostatin and releasing growth hormone at a steady pace. There are findings that make ipamorelin one of the best peptides in releasing growth hormone because it does not induce hunger and produces the hormone at a steady pace.
Once ipamorelin is administered, it can stay active at optimal level for up to 3 hours. The pulse is then sent from the point of origin to the desired receptor. Once the signaling cascade has been triggered, it then moves to the cell where it supports muscle development and avoids interference with bone growth or cartilage. This is beneficial because it may promote lean body mass and accentuates muscle growth with the possibility of improving performance. Compared to the synthetic human growth hormone, ipamorelin is preferred because it does not cause the swelling of joints and carpal tunnel syndrome. The peptide has shown the ability to boost cell synthesis, boost Ghrelin level in the stomach and increase insulin secretion from the pancreatic tissue. Collectively, all these activities are important in facilitating the transportation of nutrients while aiding fat loss and development of lean muscles. Ipamorelin increases cell synthesis, development and maturity. Moreover, it elevates the levels of insulin from and Ghrelin from stomach lining. All these processes are important in shuttling of nutrients and building of lean muscle mass.
Ipamorelin is a secretagogue peptide, implying that it plays an important role in the control of body homeostasis and weight. The peptide is known to accentuate the release of growth hormone from the anterior lobe of the pituitary gland. The peptide is a new wave in the growth hormone releasing peptides category. It has enhanced potency and long-lasting effect than the naturally produced peptide and it has a better efficacy than its predecessors GHRP-2 and GHRP-6 do. Ipamorelin is a is pentapeptide with amino acid sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 and a molecular mass of 0.711 Daltons. Nevertheless, the peptide is very powerful and aids the release of the growth hormone from the pituitary gland. The molecular weight of the peptide has substantially increased muscle growth and improved fat burning ability simultaneously. It is classified as growth hormone releasing peptides or what is commonly called GHRPs.
This category of peptide is essential in accentuating the release of growth hormone from the pituitary gland. Similarly, the growth hormone releasing hormone or GHRH have shown to have a positive feedback mechanism in the release of growth hormone from the somatotropes located in the pituitary gland. The peptides are important in accentuating somatotropes to produce and distribute the hormone to the target receptors in the body of the organism. The secretion of the growth hormone from the pituitary cells on the anterior lobe was discovered in the early 1990s. The secretion of the peptide from the pituitary cells has attracted numerous researchers since hormonal deficiency and failure of receptors to get the hormone has caused various challenges.